The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway | Zendy

Weijie Liang | Zendy; Meiji Chen | Zendy; Dongdan Zheng | Zendy; Li Jianhao | Zendy; Mingcai Song | Zendy; Wenzhu Zhang | Zendy; Jianqiang Feng | Zendy; Jun Lan | Zendy

Open Access

The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway

Author(s) -

Weijie Liang,

Meiji Chen,

Dongdan Zheng,

Li Jianhao,

Mingcai Song,

Wenzhu Zhang,

Jianqiang Feng,

Jun Lan

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000461391

Subject(s) - inflammation , necroptosis , tlr4 , microbiology and biotechnology , chemistry , signal transduction , pharmacology , apoptosis , programmed cell death , medicine , biology , biochemistry , immunology

Hyperglycemia activates multiple signaling molecules, including reactive oxygen species (ROS), toll-like receptor 4 (TLR4), receptor-interacting protein 3 (RIP3, a kinase promoting necroptosis), which mediate hyperglycemia-induced cardiac injury. This study explored whether inhibition of ROS-TLR4-necroptosis pathway contributed to the protection of ATP-sensitive K+ (KATP) channel opening against high glucose-induced cardiac injury and inflammation.

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