Open AccessA Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells
Author(s) -
XiaoJian Han,
Shuai Zhen,
Zhongxue Ye,
Jiaojiao Lu,
Lijie Wang,
Li Pan,
Jie Li,
Xia Zheng,
Huijin Li,
Wei Chen,
Li Xu,
Le Zhao
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000460618
Subject(s) - cisplatin , ectopic expression , ovarian cancer , dnmt1 , microrna , cancer research , methylation , downregulation and upregulation , flow cytometry , chemistry , apoptosis , microbiology and biotechnology , dna methylation , dna methyltransferase , cell culture , cancer , biology , methyltransferase , gene expression , chemotherapy , gene , genetics , biochemistry
Many microRNAs (miRs) are dysregulated in cancers, and aberrant miR expression patterns have been suggested to correlate with chemo-resistance of cancer cells. We aim to study the role of miR-30 family members in cisplatin-resistance of ovarian cancer cells.