Open AccessBone Metastases in Patients with Neuroendocrine Neoplasm: Frequency and Clinical, Therapeutic, and Prognostic Relevance
Author(s) -
Michael E. Scharf,
Vanessa Petry,
Hanna Daniel,
Anja Rinke,
Thomas M. Gress
Publication year - 2017
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000457954
Subject(s) - medicine , neuroendocrine tumors , stage (stratigraphy) , incidence (geometry) , radionuclide therapy , gastroenterology , radiation therapy , pancreas , log rank test , clinical significance , disease , survival analysis , oncology , paleontology , physics , optics , biology
The incidence and prevalence of neuroendocrine neoplasms (NEN) are rising. In view of continuously improving imaging techniques, more than half of the patients present with distant metastases at initial diagnosis. An advanced disease stage negatively correlates with the 5-year survival rate. In stage IV disease, bone metastases (BM) are frequent, yet knowledge concerning their clinical or prognostic relevance is rare. This study presents a single-center experience on the frequency and management of BM in patients with gastroenteropancreatic NEN and lung carcinoids.