Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration | Zendy

Ricardo Taipa | Zendy; Paulo Brochado | Zendy; Andrew Robinson | Zendy; Inês Reis | Zendy; Patrí­cio Costa | Zendy; David M. A. Mann | Zendy; Manuel Melo Pires | Zendy; Nuno Sousa | Zendy

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Patterns of Microglial Cell Activation in Alzheimer Disease and Frontotemporal Lobar Degeneration

Author(s) -

Ricardo Taipa,

Paulo Brochado,

Andrew Robinson,

Inês Reis,

Patrício Costa,

David M. A. Mann,

Manuel Melo Pires,

Nuno Sousa

Publication year - 2017

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000457127

Subject(s) - frontotemporal lobar degeneration , microglia , frontotemporal dementia , neuroscience , degeneration (medical) , alzheimer's disease , medicine , disease , neurodegeneration , neuronal degeneration , pathology , dementia , psychology , inflammation

Microglia-driven neuroinflammation can play an important role in the pathophysiology of neurodegenerative disorders. In this study, we sought to characterize the distribution of microglial cell activation in 2 neurodegenerative dementias with distinct protein signatures, Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) of the TDP subtype, and to determine if there was an anatomical correlation with the phenotypes most commonly associated with these conditions.

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