Open AccessMiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture
Author(s) -
Liqian Sun,
Manman Zhao,
Jingbo Zhang,
Ming Lv,
Youxiang Li,
Xiaoling Yang,
Aihua Liu,
Zhongxue Wu
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000456887
Subject(s) - downregulation and upregulation , phenotype , vascular smooth muscle , microbiology and biotechnology , cancer research , aneurysm , phenotypic switching , signal transduction , smooth muscle , medicine , biology , chemistry , gene , surgery , biochemistry
Our previous microarray results identified numerous microRNAs (miRNAs), including miR-29b, that were differentially expressed in the serum of intracranial aneurysm (IA) patients. The current study aimed to investigate whether miR-29b downregulation in IA could promote the phenotypic modulation of vascular smooth muscle cells (VSMCs) involved in the pathogenesis of aneurysm by activating ATG14-mediated autophagy.