MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture | Zendy

Liqian Sun | Zendy; Manman Zhao | Zendy; Jingbo Zhang | Zendy; Ming Lv | Zendy; Youxiang Li | Zendy; Xinjian Yang | Zendy; Aihua Liu | Zendy; Zhongxue Wu | Zendy

Open Access

MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture

Author(s) -

Liqian Sun,

Manman Zhao,

Jingbo Zhang,

Ming Lv,

Youxiang Li,

Xinjian Yang,

Aihua Liu,

Zhongxue Wu

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000456887

Subject(s) - downregulation and upregulation , gene knockdown , autophagy , vascular smooth muscle , phenotype , microrna , western blot , reporter gene , cancer research , transfection , microbiology and biotechnology , biology , chemistry , gene expression , endocrinology , gene , apoptosis , biochemistry , smooth muscle

Our previous microarray results identified numerous microRNAs (miRNAs), including miR-29b, that were differentially expressed in the serum of intracranial aneurysm (IA) patients. The current study aimed to investigate whether miR-29b downregulation in IA could promote the phenotypic modulation of vascular smooth muscle cells (VSMCs) involved in the pathogenesis of aneurysm by activating ATG14-mediated autophagy.

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