Open AccessA New Perspective for Osteosarcoma Therapy: Proteasome Inhibition by MLN9708/2238 Successfully Induces Apoptosis and Cell Cycle Arrest and Attenuates the Invasion Ability of Osteosarcoma Cells in Vitro
Author(s) -
Renhao Liu,
Chunjiang Fu,
Jiamei Sun,
Xvming Wang,
Shuo Geng,
Xiaoyu Wang,
Jilong Zou,
Bi Zhang,
Chenglin Yang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000456598
Subject(s) - proteasome , apoptosis , proteasome inhibitor , xiap , osteosarcoma , cell cycle , cell growth , microbiology and biotechnology , mg132 , cancer research , intracellular , cell cycle checkpoint , cancer cell , cell , hela , medicine , programmed cell death , biology , cancer , caspase , biochemistry
The proteasome exists in all eukaryotic cells and provides the main route of intracellular proteins degradation involved in cell growth and apoptosis. Proteasome inhibition could block protein degradation pathways and disturb regulatory networks, possibly leading to profound effects on cell growth, particularly in cancer cells. A proteasome inhibitor with an appropriate toxicity index for malignant cells rather than normal cells would be an attractive anticancer therapy.