Open AccessLipopeptide-Induced Suicidal Erythrocyte Death Correlates with the Degree of Acylation
Author(s) -
Abdulla Al Mamun Bhuyan,
Minh Thu Nguyen,
Rosi Bissinger,
Friedrich Götz,
Florian Läng
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000456147
Subject(s) - phosphatidylserine , ceramide , lipopeptide , lipid signaling , chemistry , biochemistry , microbiology and biotechnology , reactive oxygen species , biology , apoptosis , biophysics , phospholipid , membrane , enzyme , bacteria , genetics
Consequences of bacterial infection include anemia, which could result from stimulation of suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Bacterial components known to stimulate eryptosis include lipopeptides. Signaling mediating the triggering of eryptosis include increased cytosolic Ca2+ activity ([Ca2+]<Sub>i</Sub>), oxidative stress and cellular accumulation of ceramide. The present study aimed to define the molecular requirements for lipopeptide-induced cell membrane scrambling.