Open AccessNogo-B Facilitates LPS-Mediated Immune Responses by Up-Regulation of TLR4-Signaling in Macrophage RAW264.7
Author(s) -
Ying Zhu,
Qiang Tong,
Yue Jia,
Yunye Ning,
Ye Xiong,
Meng Yang,
Hua Xiao,
Jian Lü,
Weizong Xu,
Jian Dong Li,
Qiang Li
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000456094
Subject(s) - tlr4 , macrophage , microbiology and biotechnology , mapk/erk pathway , immune system , signal transduction , biology , kinase , iκbα , chemistry , immunology , nf κb , biochemistry , in vitro
Nogo-B, a member of the reticulon family of proteins, is mainly located in the endoplasmic reticulum (ER). Here, we investigate the function and mechanism of Nogo-B in the regulation of TLR4-associated immune responses in the macrophage cell line of RAW264.7.