Open AccessSimulated Microgravity Promotes Angiogenesis through RhoA-Dependent Rearrangement of the Actin Cytoskeleton
Author(s) -
Fei Shi,
Yongchun Wang,
Zebing Hu,
Haiyan Xu,
Jing Sun,
Yuan Gao,
Xiaotao Li,
Cuili Yang,
Chao Xie,
Chengfei Li,
Shu Zhang,
Jian Zhao,
Xinsheng Cao,
Xuegang Sun
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000456060
Subject(s) - rhoa , microbiology and biotechnology , angiogenesis , cytoskeleton , actin cytoskeleton , actin , umbilical vein , chemistry , stress fiber , wound healing , cell , biology , focal adhesion , signal transduction , biochemistry , cancer research , immunology , in vitro
Microgravity leads to hydrodynamic alterations in the cardiovascular system and is associated with increased angiogenesis, an important aspect of endothelial cell behavior to initiate new vessel growth. Given the critical role of Rho GTPase-dependent cytoskeleton rearrangement in cell migration, small GTPase RhoA might play a potential role in microgravity-induced angiogenesis.