Open AccessInhibition of TRPC6 Signal Pathway Alleviates Podocyte Injury Induced by TGF-β1
Author(s) -
Haiting Huang,
Yun You,
Xu Lin,
Chunrong Tang,
Xiangjun Gu,
Meirong Huang,
Youling Qin,
Junhua Tan,
Feifan Huang
Publication year - 2017
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000455985
Subject(s) - nephrin , gene knockdown , trpc6 , podocyte , transforming growth factor , desmin , apoptosis , biology , downregulation and upregulation , microbiology and biotechnology , endocrinology , cancer research , chemistry , medicine , kidney , immunology , receptor , biochemistry , vimentin , immunohistochemistry , transient receptor potential channel , gene , proteinuria
Transforming growth factor beta 1 (TGF-β1) plays a critical role in the pathogenesis of glomerulosclerosis. The purpose of this study was to examine the effects of inhibition of transient receptor potential cation channel C6 (TRPC6) on podocyte injury induced by TGF-β1 via nephrin and desmin mechanisms.