Open AccessHER2-Positive Neuroendocrine Breast Cancer: Case Report and Review of Literature
Author(s) -
Arpine Gevorgyan,
Giacomo Bregni,
Giulia Galli,
Elisa Zanardi,
Filippo de Braud,
Serena Di Cosimo
Publication year - 2016
Publication title -
breast care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.767
H-Index - 30
eISSN - 1661-3805
pISSN - 1661-3791
DOI - 10.1159/000453572
Subject(s) - medicine , neuroendocrine carcinoma , immunohistochemistry , quadrantectomy , breast cancer , breast carcinoma , oncology , pathological , neuroendocrine tumors , carcinoma , pathology , cancer , mastectomy
Background: Neuroendocrine carcinoma is an uncommon histology for breast cancer. Case Report: Our patient underwent right quadrantectomy for a neuroendocrine carcinoma in 1984 and had a bone relapse 30 years later. After thorough pathological and immunohistochemical analysis the diagnosis was confirmed and HER2 amplification was observed. Here we discuss the management, rationale and results of HER2-targeted therapy in advanced neuroendocrine breast carcinoma.