MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis | Zendy

Haoyu Wu | Zendy; Tao Huang | Zendy; Liang Ying | Zendy; Conghui Han | Zendy; Dawei Li | Zendy; Yao Xu | Zendy; Ming Zhang | Zendy; Shan Mou | Zendy; Zhen Dong | Zendy

Open Access

MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis

Author(s) -

Haoyu Wu,

Tao Huang,

Liang Ying,

Conghui Han,

Dawei Li,

Yao Xu,

Ming Zhang,

Shan Mou,

Zhen Dong

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453218

Subject(s) - pyroptosis , renal ischemia , reperfusion injury , ischemia , transplantation , kidney , medicine , western blot , programmed cell death , apoptosis , biology , pathology , biochemistry , gene

Ischemia/reperfusion injury (IRI) plays a crucial role in renal transplantation and can cause renal failure associated with pyroptosis, a pro-inflammatory-induced programmed cell death. Small endogenous non-coding RNAs have been shown to be involved in renal ischemia/reperfusion injury. This study was performed to investigate which miRNAs regulate pyroptosis in response to renal ischemia/reperfusion injury and determine the mechanism underlying this regulation.

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