Open AccessMiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis
Author(s) -
Haoyu Wu,
Tao Huang,
Liang Ying,
Conghui Han,
Dawei Li,
Yao Xu,
Ming Zhang,
Shan Mou,
Zhong Dong
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453218
Subject(s) - pyroptosis , renal ischemia , reperfusion injury , ischemia , transplantation , kidney , medicine , western blot , programmed cell death , apoptosis , biology , pathology , biochemistry , gene
Ischemia/reperfusion injury (IRI) plays a crucial role in renal transplantation and can cause renal failure associated with pyroptosis, a pro-inflammatory-induced programmed cell death. Small endogenous non-coding RNAs have been shown to be involved in renal ischemia/reperfusion injury. This study was performed to investigate which miRNAs regulate pyroptosis in response to renal ischemia/reperfusion injury and determine the mechanism underlying this regulation.