Open AccessBlocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy
Author(s) -
Jie Wei,
Hua Jiang,
Hongrui Gao,
Guangjie Wang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453207
Subject(s) - pi3k/akt/mtor pathway , ribosomal protein s6 , vascular endothelial growth factor , p70 s6 kinase 1 , signal transduction , rptor , vascular endothelial growth factor a , hypoxia inducible factors , phosphorylation , chemistry , endocrinology , microbiology and biotechnology , medicine , cancer research , biology , vegf receptors , biochemistry , gene
Prior studies demonstrate that hypoxia inducible factor subtype 1α (HIF-1α) in retinal tissues is involved in development of diabetic retinopathy (DR). In this report, we particularly examined the role played by mammalian target of rapamycin (mTOR) in regulating expression of HIF-1α and its downstream pathway, namely vascular endothelial growth factor (VEGF).