Open AccessMechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes
Author(s) -
Janire Urrutia,
Aintzane Alday,
Mónica Gallego,
L Layse Malagueta-Vieira,
Iván A. Aréchiga-Figueroa,
Óscar Casis,
José A. Sánchez-Chapula
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453180
Subject(s) - myocyte , hek 293 cells , pharmacology , chemistry , herg , medicine , microbiology and biotechnology , biology , receptor , potassium channel
The rapid delayed rectifier K+ current (IKr), carried by the hERG protein, is one of the main repolarising currents in the human heart and a reduction of this current increases the risk of ventricular fibrillation. α1-adrenoceptors (α1-AR) activation reduces IKr but, despite the clear relationship between an increase in the sympathetic tone and arrhythmias, the mechanisms underlying the α1-AR regulation of the hERG channel are controversial. Thus, we aimed to investigate the mechanisms by which α1-AR stimulation regulates IKr.