Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes | Zendy

Janire Urrutia | Zendy; Aintzane Alday | Zendy; Mónica Gallego | Zendy; L. Layse Malagueta-Vieira | Zendy; Iván A. AréchigaFigueroa | Zendy; Óscar Casis | Zendy; José A. SánchezChapula | Zendy

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Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes

Author(s) -

Janire Urrutia,

Aintzane Alday,

Mónica Gallego,

L. Layse Malagueta-Vieira,

Iván A. AréchigaFigueroa,

Óscar Casis,

José A. SánchezChapula

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000453180

Subject(s) - myocyte , hek 293 cells , pharmacology , chemistry , herg , medicine , microbiology and biotechnology , biology , receptor , potassium channel

The rapid delayed rectifier K+ current (IKr), carried by the hERG protein, is one of the main repolarising currents in the human heart and a reduction of this current increases the risk of ventricular fibrillation. α1-adrenoceptors (α1-AR) activation reduces IKr but, despite the clear relationship between an increase in the sympathetic tone and arrhythmias, the mechanisms underlying the α1-AR regulation of the hERG channel are controversial. Thus, we aimed to investigate the mechanisms by which α1-AR stimulation regulates IKr.

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