Open AccessPHLDA1 Promotes Lung Contusion by Regulating the Toll-Like Receptor 2 Signaling Pathway
Author(s) -
Shaohua Wang,
Hua Zhang,
An Wang,
Dayu Huang,
Jie Fan,
Lu Lu,
Xiaofeng Chen
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453173
Subject(s) - tlr2 , lung , tumor necrosis factor alpha , proinflammatory cytokine , receptor , signal transduction , inflammation , apoptosis , chemokine , cancer research , medicine , biology , immunology , pathology , microbiology and biotechnology , tlr4 , biochemistry
Lung contusion is a potentially lethal injury. Pleckstrin homology-like domain family A, member-1 (PHLDA1) is known to play crucial roles in cell proliferation and apoptosis. In this study, we investigated the biological role of PHLDA1 in lung contusion.