Open AccessCFTR Controls the Activity of NF-κB by Enhancing the Degradation of TRADD
Author(s) -
Hua Wang,
Liudmila Cebotaru,
Ha Won Lee,
Qingfeng Yang,
B. Pollard,
Harvey B. Pollard,
William B. Guggino
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453162
Subject(s) - tradd , nf κb , chemistry , microbiology and biotechnology , small hairpin rna , tumor necrosis factor alpha , nfkb1 , gene knockdown , signal transduction , biology , biochemistry , transcription factor , immunology , programmed cell death , apoptosis , death domain , gene
Chronic lung infection in cystic fibrosis leads to an inflammatory response that persists because of the chronic presence of bacteria and ultimately leads to a catastrophic failure of lung function.