Open AccessProtective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
Author(s) -
Juman Li,
Xiaojie Wei,
Qiuqiao Xie,
Thi Thai Hoa Pham,
Jinbin Wei,
Ping He,
Yang Jiao,
Xiaogang Xu,
Thi Huong Nguyen,
Qian Wen,
Renbin Huang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000453156
Subject(s) - medicine , endocrinology , insulin resistance , adipocyte , adipose tissue , glutathione peroxidase , insulin , malondialdehyde , biology , chemistry , superoxide dismutase , oxidative stress
The roots of Averrhoa carambola L. (Oxalidaceae) have long been used as a traditional Chinese medicine for the treatment of diabetes and diabetes-related diseases. 2-dodecyl-6-methoxycycyclohexa-2,5-1,4-dione (DMDD) has been isolated from A. carambola L. roots, and this study was carried out to investigate the potential beneficial effects of DMDD on obesity and insulin resistance induced by a high-fat diet (HFD) in mice.