The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations | Zendy

Christopher R. D’Adamo | Zendy; Valerie J. Dawson | Zendy; Kathleen A. Ryan | Zendy; Laura M. YergesArmstrong | Zendy; Richard D. Semba | Zendy; Nanette Steinle | Zendy; Braxton D. Mitchell | Zendy; Alan R. Shuldiner | Zendy; Patrick F. McArdle | Zendy

Open Access

The <b><i>CAPN2/CAPN8</i></b> Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations

Author(s) -

Christopher R. D’Adamo,

Valerie J. Dawson,

Kathleen A. Ryan,

Laura M. YergesArmstrong,

Richard D. Semba,

Nanette Steinle,

Braxton D. Mitchell,

Alan R. Shuldiner,

Patrick F. McArdle

Publication year - 2016

Publication title -

lifestyle genomics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.542

H-Index - 30

eISSN - 2504-3188

pISSN - 2504-3161

DOI - 10.1159/000452890

Subject(s) - biology , chemistry , genetics , endocrinology

Alpha-carotene is a provitamin A carotenoid present in fruits and vegetables. Higher serum concentrations of α-carotene have been associated with lower risk of cancer and all-cause mortality. Previous studies have suggested that genetic variants influence serum concentrations of provitamin A carotenoids, but to date no variants have been robustly associated with serum α-carotene concentrations. The aim of this study was to identify genetic associations with serum α-carotene concentrations using the genome-wide association study (GWAS) approach.

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