Open AccessThe <b><i>CAPN2/CAPN8</i></b> Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations
Author(s) -
Christopher R. D’Adamo,
Valerie J. Dawson,
Kathleen A. Ryan,
Laura M. YergesArmstrong,
Richard D. Semba,
Nanette Steinle,
Braxton D. Mitchell,
Alan R. Shuldiner,
Patrick F. McArdle
Publication year - 2016
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000452890
Subject(s) - biology , chemistry , genetics , endocrinology
Alpha-carotene is a provitamin A carotenoid present in fruits and vegetables. Higher serum concentrations of α-carotene have been associated with lower risk of cancer and all-cause mortality. Previous studies have suggested that genetic variants influence serum concentrations of provitamin A carotenoids, but to date no variants have been robustly associated with serum α-carotene concentrations. The aim of this study was to identify genetic associations with serum α-carotene concentrations using the genome-wide association study (GWAS) approach.