A Single Oral Dose of Geranylgeranylacetone Upregulates Vascular Endothelial Growth Factor and Protects against Kainic Acid-Induced Neuronal Cell Death: Involvement of the Phosphatidylinositol-3 Kinase/Akt Pathway | Zendy

Yukari Kawasaki | Zendy; Minoru Fujiki | Zendy; Susumu Uchida | Zendy; Masaki Morishige | Zendy; Yasutomo Momii | Zendy; Keisuke Ishii | Zendy

Open Access

A Single Oral Dose of Geranylgeranylacetone Upregulates Vascular Endothelial Growth Factor and Protects against Kainic Acid-Induced Neuronal Cell Death: Involvement of the Phosphatidylinositol-3 Kinase/Akt Pathway

Author(s) -

Yukari Kawasaki,

Minoru Fujiki,

Susumu Uchida,

Masaki Morishige,

Yasutomo Momii,

Keisuke Ishii

Publication year - 2017

Publication title -

pathobiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.941

H-Index - 53

eISSN - 1423-0291

pISSN - 1015-2008

DOI - 10.1159/000452862

Subject(s) - neuroprotection , protein kinase b , wortmannin , pi3k/akt/mtor pathway , pharmacology , kainic acid , phosphatidylinositol , programmed cell death , vascular endothelial growth factor , kinase , chemistry , signal transduction , medicine , apoptosis , biochemistry , receptor , glutamate receptor , vegf receptors

Previous studies demonstrated the cytoprotective effect of geranylgeranylacetone (GGA), a heat shock protein inducer, against ischemic insult or kainic acid (KA)-induced neuronal cell death. Phosphatidylinositol-3 kinase (PI3K)/Akt is thought to be an important factor that mediates neuroprotection. However, the signaling pathways in the brain in vivo after oral GGA administration remain unclear.

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