Open AccessA Single Oral Dose of Geranylgeranylacetone Upregulates Vascular Endothelial Growth Factor and Protects against Kainic Acid-Induced Neuronal Cell Death: Involvement of the Phosphatidylinositol-3 Kinase/Akt Pathway
Author(s) -
Yukari Kawasaki,
Minoru Fujiki,
Susumu Uchida,
Masaki Morishige,
Yasutomo Momii,
Keisuke Ishii
Publication year - 2017
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000452862
Subject(s) - neuroprotection , protein kinase b , wortmannin , pi3k/akt/mtor pathway , pharmacology , kainic acid , phosphatidylinositol , programmed cell death , vascular endothelial growth factor , kinase , chemistry , signal transduction , medicine , apoptosis , biochemistry , receptor , glutamate receptor , vegf receptors
Previous studies demonstrated the cytoprotective effect of geranylgeranylacetone (GGA), a heat shock protein inducer, against ischemic insult or kainic acid (KA)-induced neuronal cell death. Phosphatidylinositol-3 kinase (PI3K)/Akt is thought to be an important factor that mediates neuroprotection. However, the signaling pathways in the brain in vivo after oral GGA administration remain unclear.