Open AccessSustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a <b><i>Spirulina</i></b>-Enriched Diet
Author(s) -
Jaspal Patil,
Ashok Matte,
Hans Nissbrandt,
Carina Mallard,
Mats Sandberg
Publication year - 2016
Publication title -
neuroimmunomodulation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.635
H-Index - 65
eISSN - 1423-0216
pISSN - 1021-7401
DOI - 10.1159/000452714
Subject(s) - gclc , gclm , substantia nigra , endocrinology , medicine , antioxidant , lipopolysaccharide , glutathione , neurotrophic factors , chemistry , pharmacology , biology , receptor , dopamine , biochemistry , dopaminergic , enzyme
Neonatal infection can sensitize the adult substantia nigra (SN) to secondary insults, causing a decrease in antioxidant capacity which may lead to Parkinson's disease in adults. We studied the prolonged effect of systemic infection by (i.p.) administration of lipopolysaccharide (LPS) on interleukin (IL)-1β, the antioxidant regulator nuclear factor-erythroid 2-related factor 2 (Nrf2), and the peroxisome proliferator-activated receptor γ coactivator (PGC)-1α in rat SN.