Sustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a Spirulina-Enriched Diet | Zendy

Jaspal Patil | Zendy; Ashok Matte | Zendy; Hans Nissbrandt | Zendy; Carina Mallard | Zendy; Mats Sandberg | Zendy

Open Access

Sustained Effects of Neonatal Systemic Lipopolysaccharide on IL-1β and Nrf2 in Adult Rat Substantia Nigra Are Partly Normalized by a <b><i>Spirulina</i></b>-Enriched Diet

Author(s) -

Jaspal Patil,

Ashok Matte,

Hans Nissbrandt,

Carina Mallard,

Mats Sandberg

Publication year - 2016

Publication title -

neuroimmunomodulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.635

H-Index - 65

eISSN - 1423-0216

pISSN - 1021-7401

DOI - 10.1159/000452714

Subject(s) - gclc , gclm , substantia nigra , endocrinology , medicine , antioxidant , lipopolysaccharide , glutathione , neurotrophic factors , chemistry , pharmacology , biology , receptor , dopamine , biochemistry , dopaminergic , enzyme

Neonatal infection can sensitize the adult substantia nigra (SN) to secondary insults, causing a decrease in antioxidant capacity which may lead to Parkinson's disease in adults. We studied the prolonged effect of systemic infection by (i.p.) administration of lipopolysaccharide (LPS) on interleukin (IL)-1β, the antioxidant regulator nuclear factor-erythroid 2-related factor 2 (Nrf2), and the peroxisome proliferator-activated receptor γ coactivator (PGC)-1α in rat SN.

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