Open AccessStimulation of Suicidal Erythrocyte Death by Rottlerin
Author(s) -
Morena Mischitelli,
Mohamed Jèmaà,
Mustafa Almasry,
Caterina Faggio,
Florian Läng
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000452569
Subject(s) - rottlerin , phosphatidylserine , ceramide , biology , extracellular , band 3 , biochemistry , microbiology and biotechnology , biophysics , annexin , chemistry , apoptosis , protein kinase c , phosphorylation , membrane protein , phospholipid , membrane
The phytochemical polyphenol rottlerin is a potent activator of diverse Ca2+ -sensitive K+ channels. Those channels play a decisive role in the execution of eryptosis, the suicidal death of erythrocytes, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Signaling involved in the stimulation of eryptosis includes increase of cytosolic Ca2+ activity ([Ca2+]i) and ceramide. The present study explored, whether rottlerin induces eryptosis and, if so, to test for the involvement of Ca2+ entry and ceramide.