Open AccessContribution of Common Variants in GABRG2, RELN and NRG3 and Interaction Networks to the Risk of Hirschsprung Disease
Author(s) -
Yan Wang,
Jun Wang,
Ying Zhou,
Zhiyun Wei,
Yongtao Xiao,
Kecheng Zhou,
Jie Wen,
Junkai Yan,
Wei Cai
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000452565
Subject(s) - biology , genetics , gene , haplotype , disease , genotype , medicine
Hirschsprung disease (HSCR) is a complex and heterogeneous disorder, characterized by a deficit in enteric nervous system. Genome-wide studies implied GABRG2, RELN and NRG3 might be involved in HSCR etiology. Here, we aimed to assess genetic variants in GABRG2, RELN and NRG3 that may confer susceptibility to HSCR and explore genetic interaction networks in HSCR.