Open AccessUrinary Periostin Excretion Predicts Renal Outcome in IgA Nephropathy
Author(s) -
Jin Ho Hwang,
Jung Pyo Lee,
Clara Tammy Kim,
Seung Hee Yang,
JinHyuk Kim,
Jung Nam An,
Kyung Chul Moon,
Hajeong Lee,
Yun Kyu Oh,
Kwon Wook Joo,
Yon Su Kim,
Yon Su Kim,
Chun Soo Lim
Publication year - 2016
Publication title -
american journal of nephrology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 85
eISSN - 1421-9670
pISSN - 0250-8095
DOI - 10.1159/000452228
Subject(s) - medicine , periostin , renal function , nephropathy , gastroenterology , kidney disease , urinary system , creatinine , nephrology , urology , glomerulosclerosis , pathology , proteinuria , kidney , endocrinology , diabetes mellitus , extracellular matrix , biology , microbiology and biotechnology
Background: Periostin is a matricellular protein and plays a vital role in tissue regeneration, fibrosis and wound healing. However, data about its significance in nephrology are limited. We investigated the correlation between urinary periostin excretion and its clinical significance including renal histologic findings and prognosis in IgA nephropathy (IgAN). Methods: Of 399 patients from a glomerulonephritis cohort recruited between January 2009 and December 2014, 314 were enrolled. Serum and urine periostin (uPOSTN) were measured using enzyme-linked immunosorbent assay. We divided the patients into 3 groups by uPOSTN/creatinine (uPOSTN/Cr): group 1 (undetectable), group 2 (lower than the median) and group 3 (higher than the median). Results: The uPOSTN level was correlated with pathologic classifications and both initial and final IDMS-MDRD estimated glomerular filtration rates (eGFRs; p 30% (p = 0.033) and ESRD and/or eGFR decrease of >50% (p = 0.046) occurred significantly more in group 3. In multivariate analysis, uPOSTN group 3 (hazards ratio 2.839, 95% CI 1.013-7.957; p = 0.047) was independently associated with ESRD in IgAN patients. Conclusion: uPOSTN/Cr value at initial diagnosis correlated with renal fibrosis and predicted the renal outcomes in patients with IgAN. It could be a promising urinary biomarker for renal fibrosis.