Open AccessDecreased Neutrophil Extracellular Trap Degradation in Shiga Toxin-Associated Haemolytic Uraemic Syndrome
Author(s) -
Jonatan Leffler,
Zoltán Prohászka,
Bálint Mikes,
György Sinkovits,
Katarzyna Ciacma,
Péter Farkas,
Marienn Réti,
Kata Kelen,
György Reusz,
Attila Szabó,
Myriam Martin,
Anna M. Blom
Publication year - 2016
Publication title -
journal of innate immunity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.078
H-Index - 64
eISSN - 1662-8128
pISSN - 1662-811X
DOI - 10.1159/000450609
Subject(s) - neutrophil extracellular traps , toxin , extracellular , trap (plumbing) , microbiology and biotechnology , neutrophile , uremic toxins , chemistry , degradation (telecommunications) , haemolytic uraemic syndrome , immunology , inflammation , biology , biochemistry , endocrinology , escherichia coli , kidney disease , telecommunications , environmental engineering , computer science , gene , engineering
Neutrophil extracellular traps (NETs) can stimulate thrombosis, and their degradation is decreased in several autoimmune disorders. It was recently reported that some patients with haemolytic uraemic syndrome (HUS) also fail to degrade NETs and that neutrophils from Shiga toxin-associated HUS are primed to form NETs.