Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain | Zendy

Zizhuo Su | Zendy; Rongjie Lin | Zendy; Yuyang Chen | Zendy; Xiaorong Shu | Zendy; Haifeng Zhang | Zendy; Shumin Liang | Zendy; Ruqiong Nie | Zendy; Jingfeng Wang | Zendy; Shuanglun Xie | Zendy

Open Access

Oxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain

Author(s) -

Zizhuo Su,

Rongjie Lin,

Yuyang Chen,

Xiaorong Shu,

Haifeng Zhang,

Shumin Liang,

Ruqiong Nie,

Jingfeng Wang,

Shuanglun Xie

Publication year - 2016

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000449387

Subject(s) - cypa , secretion , myosin light chain kinase , vascular smooth muscle , chemistry , actin , cytochalasin , myosin , microbiology and biotechnology , cyclophilin a , biology , endocrinology , biochemistry , cell , cytoskeleton , smooth muscle

Accumulation of cyclophilin A (CyPA) within atherosclerotic lesions is thought to be implicated in the progression of atherosclerosis. However, the source of CyPA within atherosclerotic lesions is still unknown. The aim of this study is to determine the role of oxidized low-density lipoproteins (ox-LDL) in vascular smooth muscle cell (VSMC)-derived CyPA secretion and the underlying mechanism.

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