Open AccessOxidized Low-Density Lipoprotein-Induced Cyclophilin A Secretion Requires ROCK-Dependent Diphosphorylation of Myosin Light Chain
Author(s) -
Ziyi Su,
Rongjie Lin,
Yuyang Chen,
Xu Shu,
Haifeng Zhang,
Shumin Liang,
Rong Nie,
Jingfeng Wang,
Shuanglun Xie
Publication year - 2016
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000449387
Subject(s) - cypa , secretion , myosin light chain kinase , vascular smooth muscle , chemistry , actin , cytochalasin , myosin , microbiology and biotechnology , cyclophilin a , biology , endocrinology , biochemistry , cell , cytoskeleton , smooth muscle
Accumulation of cyclophilin A (CyPA) within atherosclerotic lesions is thought to be implicated in the progression of atherosclerosis. However, the source of CyPA within atherosclerotic lesions is still unknown. The aim of this study is to determine the role of oxidized low-density lipoproteins (ox-LDL) in vascular smooth muscle cell (VSMC)-derived CyPA secretion and the underlying mechanism.