Open AccessTransplantation of Autologous Bone Marrow Mononuclear Cells Regulates Inflammation in a Rabbit Model of Carotid Artery Atherosclerosis
Author(s) -
Kefei Cui,
Min Wang,
Lie Yu,
Xiao Ren,
Hui Cui,
Xiao Yu,
Suyun Hou,
Chao Fu,
Jian Wang
Publication year - 2016
Publication title -
journal of vascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.58
H-Index - 74
eISSN - 1423-0135
pISSN - 1018-1172
DOI - 10.1159/000449201
Subject(s) - medicine , transplantation , inflammation , bone marrow , pathology , h&e stain , peripheral blood mononuclear cell , staining , biology , biochemistry , in vitro
It is well known that inflammation plays key roles in the development of atherosclerosis and that the transplantation of bone marrow mononuclear cells (BMMNCs) can suppress inflammation in rodent models of ischemic diseases. Here, we explored whether transplantation of autologous BMMNCs could prevent the progression of atherosclerosis by the alleviation of inflammatory responses in a rabbit model of carotid artery atherosclerosis.