Comparative Pre-Emptive Analgesic Efficacy Study of Novel Antiepileptic Agents Lamotrigine and Topiramate in Patients Undergoing Major Surgeries at a Tertiary Care Hospital: A Randomized Double Blind Clinical Trial | Zendy

Ankush Gupta | Zendy; Uma Bhosale | Zendy; Priyank Shah | Zendy; Radha Yegnanarayan | Zendy; Shalini Sardesai | Zendy

Open Access

Comparative Pre-Emptive Analgesic Efficacy Study of Novel Antiepileptic Agents Lamotrigine and Topiramate in Patients Undergoing Major Surgeries at a Tertiary Care Hospital: A Randomized Double Blind Clinical Trial

Author(s) -

Ankush Gupta,

Uma Bhosale,

Priyank Shah,

Radha Yegnanarayan,

Shalini Sardesai

Publication year - 2016

Publication title -

annals of neurosciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.545

H-Index - 19

eISSN - 0976-3260

pISSN - 0972-7531

DOI - 10.1159/000449182

Subject(s) - topiramate , lamotrigine , medicine , anesthesia , antiepileptic drug , analgesic , randomized controlled trial , double blind , clinical trial , tertiary care , anticonvulsant , epilepsy , surgery , psychiatry , alternative medicine , placebo , pathology

Central nervous sensitization, following surgical injury, leads to postoperative pain hypersensitivity due to lowered pain threshold in peripheral nociceptors and increased excitability of spinal neurons. Pre-emptive analgesia is intended to decrease pain perception and overall analgesic need by use of drug regimen, seizing CNS sensitization before exposure to painful stimuli. Few studies support pre-emptive analgesic efficacy of novel antiepileptic agent Gabapentin. Though Topiramate and Lamotrigine have been proven analgesic in animal models of chronic pain and clinical studies of Gabapentin-resistant neuropathic pain, literature search revealed scarce data on its pre-emptive analgesic efficacy.

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