Open AccessComparative Pre-Emptive Analgesic Efficacy Study of Novel Antiepileptic Agents Lamotrigine and Topiramate in Patients Undergoing Major Surgeries at a Tertiary Care Hospital: A Randomized Double Blind Clinical Trial
Author(s) -
Ankush Gupta,
Uma A Bhosale,
Priyank Shah,
Radha Yegnanarayan,
Shalini Sardesai
Publication year - 2016
Publication title -
annals of neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 19
eISSN - 0976-3260
pISSN - 0972-7531
DOI - 10.1159/000449182
Subject(s) - topiramate , lamotrigine , medicine , anesthesia , antiepileptic drug , analgesic , randomized controlled trial , double blind , clinical trial , tertiary care , anticonvulsant , epilepsy , surgery , psychiatry , alternative medicine , placebo , pathology
Central nervous sensitization, following surgical injury, leads to postoperative pain hypersensitivity due to lowered pain threshold in peripheral nociceptors and increased excitability of spinal neurons. Pre-emptive analgesia is intended to decrease pain perception and overall analgesic need by use of drug regimen, seizing CNS sensitization before exposure to painful stimuli. Few studies support pre-emptive analgesic efficacy of novel antiepileptic agent Gabapentin. Though Topiramate and Lamotrigine have been proven analgesic in animal models of chronic pain and clinical studies of Gabapentin-resistant neuropathic pain, literature search revealed scarce data on its pre-emptive analgesic efficacy.