Open AccessPhosphorylation of STAT3 in Undifferentiated Pleomorphic Sarcoma Is Correlated with a Favorable Prognosis
Author(s) -
Hirofumi Bekki,
Kenichi Kohashi,
Yuichi Yamada,
Kunio Iura,
Takeaki Ishii,
Akira Maekawa,
Hiroshi Otsuka,
Hidetaka Yamamoto,
Michiyuki Hakozaki,
Kazuki Nabeshima,
Yukihide Iwamoto,
Yoshinao Oda
Publication year - 2016
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000448524
Subject(s) - stat protein , janus kinase , stat3 , socs3 , stat , protein kinase b , cancer research , phosphorylation , immunohistochemistry , biology , mapk/erk pathway , signal transduction , kinase , blot , cytokine , microbiology and biotechnology , immunology , gene , biochemistry
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays a role in various biological processes. Phosphorylated STAT3 (p-STAT3) functions as a transcriptional factor, and suppressor of cytokine signaling 3 (SOCS3) is a potential inhibitor of STAT3. Here, we analyzed the status of the JAK-STAT pathway in undifferentiated pleomorphic sarcoma (UPS).