Open AccessWIN 55,212-2 Inhibits the Epithelial Mesenchymal Transition of Gastric Cancer Cells via COX-2 Signals
Author(s) -
Xiang-Shu Xian,
Lanqing Huang,
Bo Zhang,
ChiRei Wu,
Jun Cui,
Zhihua Wang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447910
Subject(s) - vimentin , epithelial–mesenchymal transition , downregulation and upregulation , protein kinase b , cancer research , cell migration , metastasis , chemistry , western blot , cancer cell , cell , cancer , biology , signal transduction , medicine , immunology , immunohistochemistry , biochemistry , gene
Cannabinoids (the active components of Cannabis sativa) and their derivatives have received considerable interest due to reports that they can affect the tumor growth, migration, and metastasis. Previous studies showed that the cannabinoid agonist WIN 55,212-2 (WIN) was associated with gastric cancer (GC) metastasis, but the mechanisms were unknown.