HDAC5 Inhibits Hepatic Lipogenic Genes Expression by Attenuating the Transcriptional Activity of Liver X Receptor | Zendy

Haiyan Jia | Zendy; Quanzhong Li | Zendy; Lifang Lv | Zendy

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HDAC5 Inhibits Hepatic Lipogenic Genes Expression by Attenuating the Transcriptional Activity of Liver X Receptor

Author(s) -

Haiyan Jia,

Quanzhong Li,

Lifang Lv

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447858

Subject(s) - liver x receptor , gene , receptor , endocrinology , medicine , gene expression , cancer research , chemistry , microbiology and biotechnology , biology , transcription factor , nuclear receptor , biochemistry

Liver X receptor (LXR), a member of the nuclear receptor superfamily, is known to induce the expression of SREBP-1c and ChREBP, two master regulators of hepatic lipogenesis. Histone deacyetylases (HDACs) have been shown to play critical roles in glucose and lipids metabolism. However, the exact role of HDAC5 in lipogenesis remains elusive.

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