Open AccessCardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice
Author(s) -
Ming Su,
Zhiguo Chen,
Wang Chang-xin,
Lingyun Song,
Yubao Zou,
Lianfeng Zhang,
Rutai Hui,
Jizheng Wang
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447853
Subject(s) - downregulation and upregulation , autophagy , heart failure , genetically modified mouse , microrna , cardiac function curve , pi3k/akt/mtor pathway , medicine , transgene , endocrinology , regulator , microbiology and biotechnology , chemistry , biology , signal transduction , apoptosis , gene , biochemistry
MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice. The miR-222 and miR-221 share the same gene cluster, however, the role of miR-222 in the regulation of cardiac function remained ill-defined.