Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice | Zendy

Ming Su | Zendy; Zhiguo Chen | Zendy; Wang Chang-xin | Zendy; Lei Song | Zendy; Yubao Zou | Zendy; Lianfeng Zhang | Zendy; Rutai Hui | Zendy; Jizheng Wang | Zendy

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Cardiac-Specific Overexpression of miR-222 Induces Heart Failure and Inhibits Autophagy in Mice

Author(s) -

Ming Su,

Zhiguo Chen,

Wang Chang-xin,

Lei Song,

Yubao Zou,

Lianfeng Zhang,

Rutai Hui,

Jizheng Wang

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447853

Subject(s) - downregulation and upregulation , autophagy , heart failure , genetically modified mouse , microrna , cardiac function curve , pi3k/akt/mtor pathway , medicine , transgene , endocrinology , regulator , microbiology and biotechnology , chemistry , biology , signal transduction , apoptosis , gene , biochemistry

MicroRNAs play a crucial role in the regulation of pathological cardiac remodeling and heart failure. Previously, we found that overexpression of miR-221 induces heart failure in mice. The miR-222 and miR-221 share the same gene cluster, however, the role of miR-222 in the regulation of cardiac function remained ill-defined.

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