Inhibition of MicroRNA-383 Ameliorates Injury After Focal Cerebral Ischemia via Targeting PPARγ | Zendy

Lichun Pei | Zendy; Songyan Meng | Zendy; Wei-Gang Yu | Zendy; Q. Wang | Zendy; Fangfang Song | Zendy; Lan Ma | Zendy

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Inhibition of MicroRNA-383 Ameliorates Injury After Focal Cerebral Ischemia via Targeting PPARγ

Author(s) -

Lichun Pei,

Songyan Meng,

Wei-Gang Yu,

Q. Wang,

Fangfang Song,

Lan Ma

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447838

Subject(s) - microrna , ischemia , antagomir , luciferase , peroxisome proliferator activated receptor , medicine , blot , receptor , chemistry , biology , transfection , cell culture , biochemistry , gene , genetics

Peroxisome proliferator-activated receptor gamma (PPARγ) plays a critical role in protecting against distinct brain damages, including ischemia. Our previous data have shown that the protein level of PPARγ is increased in the cortex after middle cerebral artery occlusion (MCAO); PPARγ up-regulation contributes to PPARγ activation and is effective in reducing ischemic damage to brain. However, the regulatory mechanism of PPARγ after focal cerebral ischemia in rats is still unclear. In this study, we evaluated the effect of microRNA on PPARγ in rats subjected to MCAO.

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