Open AccessExpression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes
Author(s) -
Shefalee K. Bhavsar,
Yogesh Singh,
Piyush Sharma,
Vishal Khairnar,
Zohreh Hosseinzadeh,
Shaqiu Zhang,
Mònica Palmada,
Ivan Sabolić,
Hermann Koepsell,
Karl S. Lang,
Philipp A. Lang,
Florian Läng
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447827
Subject(s) - cytotoxic t cell , jurkat cells , glucose uptake , microbiology and biotechnology , biology , chemistry , t cell , biochemistry , endocrinology , immune system , in vitro , immunology , insulin
Similar to tumor cells, activated T-lymphocytes generate ATP mainly by glycolytic degradation of glucose. Lymphocyte glucose uptake involves non-concentrative glucose carriers of the GLUT family. In contrast to GLUT isoforms, Na+-coupled glucose-carrier SGLT1 accumulates glucose against glucose gradients and is effective at low extracellular glucose concentrations. The present study explored expression and regulation of SGLT1 in activated murine splenic cytotoxic T cells (CTLs) and human Jurkat T cells.