Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes | Zendy

Shefalee K. Bhavsar | Zendy; Yogesh Singh | Zendy; Piyush Sharma | Zendy; Vishal Khairnar | Zendy; Zohreh Hosseinzadeh | Zendy; Shaqiu Zhang | Zendy; Mònica Palmada | Zendy; Ivan Sabolić | Zendy; Hermann Koepsell | Zendy; Karl S. Lang | Zendy; Philipp A. Lang | Zendy; Florian Läng | Zendy

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Expression of JAK3 Sensitive Na+ Coupled Glucose Carrier SGLT1 in Activated Cytotoxic T Lymphocytes

Author(s) -

Shefalee K. Bhavsar,

Yogesh Singh,

Piyush Sharma,

Vishal Khairnar,

Zohreh Hosseinzadeh,

Shaqiu Zhang,

Mònica Palmada,

Ivan Sabolić,

Hermann Koepsell,

Karl S. Lang,

Philipp A. Lang,

Florian Läng

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447827

Subject(s) - cytotoxic t cell , jurkat cells , glucose uptake , microbiology and biotechnology , biology , chemistry , t cell , biochemistry , endocrinology , immune system , in vitro , immunology , insulin

Similar to tumor cells, activated T-lymphocytes generate ATP mainly by glycolytic degradation of glucose. Lymphocyte glucose uptake involves non-concentrative glucose carriers of the GLUT family. In contrast to GLUT isoforms, Na+-coupled glucose-carrier SGLT1 accumulates glucose against glucose gradients and is effective at low extracellular glucose concentrations. The present study explored expression and regulation of SGLT1 in activated murine splenic cytotoxic T cells (CTLs) and human Jurkat T cells.

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