Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes | Zendy

Xu Yan | Zendy; Jianxun Liu | Zendy; Hongjin Wu | Zendy; Yuna Liu | Zendy; Sidao Zheng | Zendy; Chengying Zhang | Zendy; Yang Cui | Zendy

Open Access

Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes

Author(s) -

Xu Yan,

Jianxun Liu,

Hongjin Wu,

Yuna Liu,

Sidao Zheng,

Chengying Zhang,

Yang Cui

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447825

Subject(s) - mtt assay , hypoxia (environmental) , flow cytometry , apoptosis , viability assay , blot , transfection , luciferase , kinase , ischemia , ginseng , pharmacology , ginsenoside , reporter gene , microbiology and biotechnology , medicine , chemistry , gene expression , gene , biology , biochemistry , pathology , alternative medicine , organic chemistry , oxygen

Ginsenoside Rb1 (GS-Rb1) is one of the most important active pharmacological extracts of the Traditional Chinese Medicine ginseng, with extensive evidence of its cardioprotective properties. Mir-208 has been shown to act as a biomarker of acute myocardial infarction in vivo studies including man. However the impact of miR-208 on the protective effect of GS-Rb1 in hypoxia/ischemia injured cardiomyocytes remains unclear. The current study aims to investigate the target gene of miR-208 and the impact on the protective effect of GS-Rb1 in hypoxia/ischemia (H/I) injuried cardiomyocytes.

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