δ-Opioid Receptor Activation and MicroRNA Expression in the Rat Heart Under Prolonged Hypoxia | Zendy

Feng Zhi | Zendy; Lian Xue | Zendy; Nan Shao | Zendy; Danni Deng | Zendy; Xuezhi Kang | Zendy; Yuan Xu | Zendy; Rong Wang | Zendy; Yilin Yang | Zendy; Ying Xia | Zendy

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δ-Opioid Receptor Activation and MicroRNA Expression in the Rat Heart Under Prolonged Hypoxia

Author(s) -

Feng Zhi,

Lian Xue,

Nan Shao,

Danni Deng,

Xuezhi Kang,

Yuan Xu,

Rong Wang,

Yilin Yang,

Ying Xia

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000447815

Subject(s) - hypoxia (environmental) , microrna , taqman , downregulation and upregulation , real time polymerase chain reaction , receptor , opioid , biology , medicine , endocrinology , pharmacology , chemistry , gene , oxygen , biochemistry , organic chemistry

Hypoxic/ischemic injury to the heart is a frequently encountered clinical problem with limited therapeutic options. Since microRNAs (miRNAs) are involved in hypoxic/ischemic events, and δ-opioid receptor (DOR) activation is known to protect against hypoxic/ischemic injury, we speculated on the involvement of DOR activation in altering miRNA expression in the heart under hypoxic conditions. The present study aimed to test our hypothesis.

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