Open Accessδ-Opioid Receptor Activation and MicroRNA Expression in the Rat Heart Under Prolonged Hypoxia
Author(s) -
Feng Zhi,
Xue Li,
Ningsheng Shao,
Danni Deng,
Xiaoming Kang,
Dongman Chao,
Yuan Xu,
Rong Wang,
Yilin Yang,
Ying Xia
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447815
Subject(s) - hypoxia (environmental) , microrna , taqman , downregulation and upregulation , real time polymerase chain reaction , receptor , opioid , biology , medicine , endocrinology , pharmacology , chemistry , gene , oxygen , biochemistry , organic chemistry
Hypoxic/ischemic injury to the heart is a frequently encountered clinical problem with limited therapeutic options. Since microRNAs (miRNAs) are involved in hypoxic/ischemic events, and δ-opioid receptor (DOR) activation is known to protect against hypoxic/ischemic injury, we speculated on the involvement of DOR activation in altering miRNA expression in the heart under hypoxic conditions. The present study aimed to test our hypothesis.