Open AccessLEFTY2 Controls Migration of Human Endometrial Cancer Cells via Focal Adhesion Kinase Activity (FAK) and miRNA-200a
Author(s) -
Nour Alowayed,
Madhuri S. Salker,
Ni Zeng,
Yogesh Singh,
Florian Läng
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000447792
Subject(s) - focal adhesion , microbiology and biotechnology , cell growth , cell migration , cancer research , microrna , cell adhesion , biology , signal transduction , cell , biochemistry , gene
LEFTY2, a suppressor of cell proliferation, tumor growth, regulator of stemness and embryonic differentiation, is a negative regulator of cancer cell reprogramming. Malignant transformation may lead to migration requiring loss of adhesion and gain of migratory activity. Signaling involved in the orchestration of migration, proliferation and spreading of cells include focal adhesion kinase (FAK) and adhesion molecule E-cadherin.