Open AccessSystemic Therapy of Advanced/Metastatic Breast Cancer - Current Evidence and Future Concepts
Author(s) -
Cornelia Liedtke,
HansChristian Kolberg
Publication year - 2016
Publication title -
breast care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.767
H-Index - 30
eISSN - 1661-3805
pISSN - 1661-3791
DOI - 10.1159/000447549
Subject(s) - medicine , metastatic breast cancer , systemic therapy , breast cancer , clinical trial , oncology , disease , chemotherapy , targeted therapy , cancer
Systemic therapy of metastatic breast cancer may include chemotherapy, endocrine therapy, and targeted therapies (e.g., antibody-based approaches). These agents may be employed alone or in combination based on the patient's breast cancer subtype. Therefore, characterization of the disease phenotype is necessary and may include biopsy of the metastatic site. Novel therapeutic approaches include immunologic therapies, PARP inhibitors, PI3K inhibitors, and CDK4/6 inhibitors, which are currently under investigation in clinical trials.