Open AccessA Review of Translocation T(6;11) Renal Cell Carcinoma Tumors in the Adult Patient
Author(s) -
Paulette Cutruzzula,
David Cahn,
Dana Kivlin,
Carmen Tong,
Daniel C. Edwards,
Melanie Amster
Publication year - 2017
Publication title -
current urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.476
H-Index - 13
eISSN - 1661-7657
pISSN - 1661-7649
DOI - 10.1159/000447154
Subject(s) - medicine , chromosomal translocation , renal cell carcinoma , pathology , population , desmoplastic small round cell tumor , carcinoma , immunohistochemistry , oncology , gene , biology , biochemistry , environmental health
Historically, T(6;11) renal cell carcinoma (RCC) has been associated with the pediatric and adolescent populations and documentation of this tumor in adults has been rare. However, the frequency of translocation renal cell carcinoma (TRCC) may be widely underestimated in the adult population due to an inadequate immunohistochemical workup or misdiagnosis from similar gross and histological findings to other RCC. A subset of MiT family translocation carcinomas, t(6:11) (p21;q12) translocation tumors cause an alpha-TFEB gene fusion. Morphologically, this neoplasm tends to mimic the various types of RCC's, including clear cell, papillary, and even epitheloid angiomyolipomas. Adult cases of TRCC have shown to behave more aggressively than their indolent pediatric counterpart, but due to the limited number of reported cases the true nature of these tumors has yet to be determined. The aim of this review is to bring an awareness of translocation RCC to better understand its diagnoses, treatment and prognosis, and, in turn, to allow for new cases to further highlight the behavior of this rare variant.