Open AccessExpression of Epidermal Growth Factor Receptor and Transforming Growth Factor Alpha in Cancer Bladder: Schistosomal and Non-Schistosomal
Author(s) -
Ahmed Badawy,
Ali El-Hindawi,
Olfat Hammam,
Mona Moussa,
Noha Helal,
Amira Kamel
Publication year - 2017
Publication title -
current urology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.476
H-Index - 13
eISSN - 1661-7657
pISSN - 1661-7649
DOI - 10.1159/000447140
Subject(s) - epidermal growth factor receptor , medicine , bladder cancer , tgf alpha , transforming growth factor , carcinogenesis , cancer research , cancer , epidermal growth factor , oncology , pathology , receptor
Overexpression of epidermal growth factor receptor (EGFR) has been described in several solid tumors including bladder cancer. Transforming growth factor alpha (TGFα) is frequently deregulated in neoplastic cells and plays a role in the development of bladder cancer. TGFα-EGFR ligand-receptor combination constitutes an important event in multistep tumorigenesis.