Open AccessDietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift
Author(s) -
Colleen G. Le Prell,
Angela Fulbright,
Christopher Spankovich,
Scott Griffiths,
Edward Lobariñas,
Kathleen C.M. Campbell,
Patrick J. Antonelli,
Glenn E. Green,
Kenneth E. Guire,
Josef M. Miller
Publication year - 2016
Publication title -
audiology and neurotology extra
Language(s) - English
Resource type - Journals
ISSN - 1664-5537
DOI - 10.1159/000446600
Subject(s) - audiology , tinnitus , loudness , medicine , auditory fatigue , placebo , carotene , vitamin , randomized controlled trial , clinical trial , dietary supplement , otoacoustic emission , hearing loss , noise exposure , food science , chemistry , alternative medicine , pathology
This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. Post-exposure TTS was measured, with no significant difference as a function of treatment. Distortion product otoacoustic emission amplitudes were suppressed after music exposure in both groups, with no significant difference as a function of treatment. Tinnitus was more likely to be reported by the treatment group, but there were no group differences in perceived loudness or bothersomeness. Taken together, this supplement had no effect on noise-induced changes in hearing. Recommendations for future clinical trials are discussed.