Open AccessDifferential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma
Author(s) -
Cláudia Veiga Chang,
Ricardo Vieira Araujo,
Cinthya dos Santos Cirqueira,
Carolina Maria Gomes Cani,
Hamilton Matushita,
Valter Ângelo Sperling Cescato,
Maria Candida Barisson Villares Fragoso,
Marcello D. Bronstein,
Maria Cláudia Nogueira Zerbini,
Berenice B. Mendonca,
Luciani R. Carvalho
Publication year - 2016
Publication title -
neuroendocrinology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.493
H-Index - 101
eISSN - 1423-0194
pISSN - 0028-3835
DOI - 10.1159/000446072
Subject(s) - pituitary adenoma , sox2 , stem cell , stem cell marker , homeobox protein nanog , pathology , biology , adenoma , immunohistochemistry , immunostaining , endocrinology , cancer research , medicine , induced pluripotent stem cell , transcription factor , microbiology and biotechnology , embryonic stem cell , biochemistry , gene
Although craniopharyngioma (CP) is histologically benign, it is a pituitary tumour that grows rapidly and often recurs. Adamantinomatous CP (ACP) was associated with an activating mutation in β-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP. Stem cells have also been identified in pituitary adenoma. Our aim was to characterize the expression pattern of ABCG2, CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, and SOX9 stem cell markers in human ACP and pituitary adenoma.