Open AccessMammalian Target of Rapamycin Signaling Pathway Changes with Intestinal Epithelial Cells Renewal Along Crypt-Villus Axis
Author(s) -
Huansheng Yang,
Xia Xiong,
Xiaocheng Wang,
Yulong Yin
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445665
Subject(s) - crypt , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , biology , intestinal epithelium , intestinal mucosa , phosphorylation , intestinal villus , epithelium , medicine , endocrinology , genetics
Understanding the mechanism that involves in regulating epithelial cells renewal is the fundamental of regulating intestinal mucosa development and functions and related diseases. The mechanistic target of rapamycin (mTOR) signaling pathway involves in controlling various major processes by integrating intracellular and extracellular cues. The present experiment was conducted to test the correlation between the mTOR signaling pathway and intestinal epithelial cells renewal along crypt-villus axis (CVA).