Open AccessSmad2/3/4 Pathway Contributes to TGF-β-Induced MiRNA-181b Expression to Promote Gastric Cancer Metastasis by Targeting Timp3
Author(s) -
Qi Zhou,
Xiao Zheng,
Lüjun Chen,
Bin Xu,
Xin Yang,
Jingting Jiang,
Changping Wu
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445638
Subject(s) - microrna , downregulation and upregulation , gene knockdown , cancer research , epithelial–mesenchymal transition , carcinogenesis , metastasis , cancer , transforming growth factor , biology , gene silencing , untranslated region , cancer cell , cell culture , transforming growth factor beta , messenger rna , microbiology and biotechnology , gene , genetics
Transforming growth factor beta (TGF-β) plays a major role in tumorigenesis. MicroRNA-181b (miRNA-181b) is a multifaceted miRNA that has been implicated in many cellular processes such as cell fate determination and cellular invasion. This study aimed to confirm the relationship of miRNA-181b and the TGF-β-Smad2/3/4 pathway with the induction of the epithelial-to-mesenchymal transition (EMT) in gastric cancer.