Open AccessMiR-410 Down-Regulates the Expression of Interleukin-10 by Targeting STAT3 in the Pathogenesis of Systemic Lupus Erythematosus
Author(s) -
Dongmei Li,
Na Zhang,
Xiaomei Zhang,
Muting Qin,
Yuzhu Dong,
Ling Jin
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445625
Subject(s) - pathogenesis , microrna , stat3 , untranslated region , immunology , three prime untranslated region , autoimmunity , messenger rna , lupus erythematosus , interleukin , medicine , biology , signal transduction , cytokine , gene , antibody , microbiology and biotechnology , genetics
Systemic lupus erythematosus (SLE) is a heterogeneous chronic inflammatory autoimmune disorder, in the pathogenesis of which miRNAs play a versatile function. The purpose of this study was to investigate the effect of miRNA-410 on the pathogenesis of SLE in T cells of SLE patients.