Open AccessMiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction
Author(s) -
Lingui Xue,
Ying Zhang,
Weijie Du,
Haihai Liang,
Hua He,
Lu Zhang,
Zhenwei Pan,
Xuelian Li,
Chaoqian Xu,
Yuhong Zhou,
Leimin Wang,
Ming Qian,
Tianyi Liu,
Hongli Yin,
Yanjie Lu,
Baofeng Yang,
Hongli Shan
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445609
Subject(s) - transfection , myocardial infarction , western blot , microrna , medicine , downregulation and upregulation , cardiology , ligation , patch clamp , regulator , endocrinology , chemistry , biology , electrophysiology , cell culture , gene , biochemistry , genetics
Acute myocardial infarction (AMI) is a devastating cardiovascular disease with a high rate of morbidity and mortality, partly due to enhanced arrhythmogenicity. MicroRNAs (miRNAs) have been shown to participate in the regulation of cardiac ion channels and the associated arrhythmias. The purpose of this study was to test our hypothesis that miR-223-3p contributes to the electrical disorders in AMI via modulating KCND2, the gene encoding voltage-gated channel Kv4.2 that carries transient outward K+ current Ito.