Open AccessDeoxygenation Affects Composition of Membrane-Bound Proteins in Human Erythrocytes
Author(s) -
Oksana Luneva,
S. V. Sidorenko,
Olga Ponomarchuk,
Artem M. Tverskoy,
Aleksander A. Cherkashin,
О. В. Родненков,
Н. В. Алексеева,
Л. И. Деев,
Г. В. Максимов,
Ryszard Grygorczyk,
Sergei N. Orlov
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445607
Subject(s) - hemolysis , erythrocyte fragility , hemoglobin , extracellular , biochemistry , hypoxia (environmental) , chemistry , membrane protein , red blood cell , deoxygenation , biology , biophysics , oxygen , microbiology and biotechnology , membrane , immunology , organic chemistry , catalysis
ATP release from erythrocyte plays a key role in hypoxia-induced elevation of blood flow in systematic circulation. We have previously shown that hemolysis contributes to erythrocyte ATP release triggered by several stimuli, including hypoxia, but the molecular mechanisms of hypoxia-increased membrane fragility remain unknown.