Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells | Zendy

Ming Tan | Zendy; Hongbing Yan | Zendy; Jiannan Li | Zendy; Wenke Li | Zendy; Yuanyuan Fu | Zendy; Wen Chen | Zendy; Zhou Zhou | Zendy

Open Access

Thrombin Stimulated Platelet-Derived Exosomes Inhibit Platelet-Derived Growth Factor Receptor-Beta Expression in Vascular Smooth Muscle Cells

Author(s) -

Ming Tan,

Hongbing Yan,

Jiannan Li,

Wenke Li,

Yuanyuan Fu,

Wen Chen,

Zhou Zhou

Publication year - 2016

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000445588

Subject(s) - microvesicles , platelet , exosome , platelet activation , microrna , thrombin , vascular smooth muscle , microbiology and biotechnology , gene silencing , biology , receptor , chemistry , endocrinology , medicine , immunology , gene , biochemistry , smooth muscle

It is difficult to predict acute thrombotic cardiovascular events in the clinic. Few studies have reported the presence of plasma exosomes containing microRNAs (miRNAs) in cardiovascular events. Therefore, we aimed to investigate the levels of miR-223, miR-339 and miR-21 in plasma exosomes before thrombosis in mouse models of carotid tandem stenosis, as well as the mechanisms underlying the origin and function of these exosomal miRNAs.

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