Open AccessP-Hydroxycinnamaldehyde Induces B16-F1 Melanoma Cell Differentiation via the RhoA-MAPK Signaling Pathway
Author(s) -
Lianmei Zhao,
Guogui Sun,
Liang Han,
Lihua Liu,
Fengzhi Ren,
Lei Li,
Ming Ma,
Baoen Shan
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445580
Subject(s) - rhoa , mapk/erk pathway , melanoma , cancer research , p38 mitogen activated protein kinases , in vivo , chemistry , lysophosphatidic acid , cell growth , downregulation and upregulation , microbiology and biotechnology , biology , signal transduction , biochemistry , receptor , gene
Due to its antitumor and gastroprotective properties, cochinchina momordica seed (CMS), has been widely used to treat cancer patients in Asia. Our previous reports have shown that CMS is able to induce the differentiation of B16-F1 melanoma cells. However, its functional component and mechanism remain unclear and are addressed in this study.