Open AccessTNF-α Activates High-Mobility Group Box 1 - Toll-Like Receptor 4 Signaling Pathway in Human Aortic Endothelial Cells
Author(s) -
Won Seok Yang,
Nam Jeong Han,
Jin Ju Kim,
Mee Jeong Lee,
Su-Kil Park
Publication year - 2016
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000445570
Subject(s) - syk , tlr4 , signal transduction , toll like receptor , microbiology and biotechnology , small interfering rna , hmgb1 , tumor necrosis factor alpha , receptor , biology , chemistry , cancer research , tyrosine kinase , transfection , immunology , cell culture , innate immune system , biochemistry , genetics
Toll-like receptor 4 (TLR4) interacts with endogenous substances as well as lipopolysaccharide. We explored whether TLR4 is implicated in tumor necrosis factor-α (TNF-α) signal transduction in human aortic endothelial cells.