Open AccessGenetic Variants of Thymic Stromal Lymphopoietin in Nonsteroidal Anti-Inflammatory Drug-Induced Urticaria/Angioedema
Author(s) -
María del Carmen Plaza-Serón,
Natalia BlancaLópez,
Natalia PérezSánchez,
Inmaculada Doña,
Marialbert AcostaHerrera,
María Pino-Yanes,
Carlos Flores,
José Antonio Cornejo-García,
James R. Perkins,
Ana Molina,
Marı́a José Torres,
Miguel Blanca,
María Gabriela Canto,
Pedro Ayuso
Publication year - 2016
Publication title -
international archives of allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.696
H-Index - 100
eISSN - 1423-0097
pISSN - 1018-2438
DOI - 10.1159/000444797
Subject(s) - thymic stromal lymphopoietin , angioedema , nonsteroidal , immunology , medicine , drug , inflammation , pharmacology
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequent agents involved in hypersensitivity drug reactions, with NSAID-induced urticaria and/or angioedema (NIUA) being the most common entity. Mast cells are key players in NIUA and are activated by thymic stromal lymphopoietin (TSLP). This cytokine functions through recognition by its receptor, composed of IL7Rα (interleukin-7 receptor alpha) and TSLPR (TSLP receptor). These genes have been previously associated with other inflammatory diseases.